Obesity may start as early as baby's bottle: researchers

GENEVA (AFP) - Early exposure to chemicals used in the making of
products such as baby bottles or plastic food wraps may lead to
obesity, according to new research presented Wednesday.

Three separate studies presented at the European Congress on Obesity in Geneva found that mice which were exposed during early development to chemicals used in products such as plastic food containers or even boat paint tended to become fat later in life.

The findings could change how obesity is viewed and dealt with, according to an expert on the subject.

Jerry Heindel from the United States National Institute of
Environmental Health Sciences said: "If these findings are proven to be
true in humans, then the focus must change from losing weight as adults
to prevention of weight gain during development, through reducing the
exposure to such substances."

In one study, female mice whose mothers were exposed to bisphenol A --
commonly used in plastic good containers and bottles -- were found to
grow up into fat mice.

Food intake and activity levels were no different between the mice who
became fat and those that did not, according to the study by Beverly
Rubin from the US Tufts University.

Another study found that pregnant mice which were exposed to the
chemical perfluorooctanoic acid -- used as a greaseproofing agent in
products such as microwave popcorn bags -- had mice which were unusually small at birth but then became overweight as adults.

Suzanne Fenton from the US Environmental Protection Agency, who
conducted the research, pointed out that the effect is only seen when
low doses are applied.

This indicates that different doses may "trigger health problems in the
body by various mechanisms or that the high doses cause more serious
problems, and potentially mask the abnormal weight gain", she said.

A third study found that when pregnant mice were treated with doses of
tributylin that is comparable to that found in humans, a genetic
programme would be triggered in their offspring, causing them to become
fat as adults.

Tributylin is a chemical used in plastic food wrap and as a fungicide.

"Developmental exposure is probably more serious than adult exposure
because the data with other such exposures suggest that the pro-obesity
reprogramming is irreversible, which means you will spend your life
fighting weight gain," said Bruce Blumberg from the University of California at Irvine who conducted the research.

The World Health Organization has estimated that over 700 million people would be obese by 2015.

The European Conference on Obesity is meeting in Geneva from May 14-17.